Adverse events: The most common adverse drug reactions (≥ 10%) in patients receiving Xofigo were nausea, diarrhea, vomiting, and peripheral edema.Dosage forms: Single-use vial at a concentration of 1000 kBq/mL (27 microcurie/mL) at the reference date with a total radioactivity of 6000 kBq/vial (162 microcurie/vial) at the reference date.Dosing: The dose regimen of Xofigo is 50 kBq (1.35 microcurie) per kg body weight, administered at 4-week intervals for 6 injections.It might be possible to store sperm before the treatment if you plan to have children in the future. Talk to your doctor or nurse about effective contraception before having the treatment. If clothing becomes soiled with urine or faeces, wash it separately from other clothingĪfter this treatment, men shouldn't father children for at least 6 months because the treatment can cause sperm damage.If you share the toilet with other people, wipe the toilet seat after using it.For 7 days, flush the toilet twice after using it.For 7 days, wipe yourself very carefully after having your bowels open (some hospitals suggest that you use gloves).Wash your hands thoroughly every time you use the toilet.For the first few days sit down on the toilet when passing urine, instead of standing up or using a urinal.The team looking after you might ask you to take the following precautions.
The total amount is extremely small and gets lower each day. After treatmentĪfter the treatment, some radiation may be present in your wee (urine) and poo (stool) for up to 7 days. You have the treatment as an outpatient and can go home afterwards. You usually have it up to 6 times. You might have a blood test in between injections to make sure it is safe for you to have your next one. You normally have the injection every 4 weeks. Usually this is through a thin short tube (cannula) which is put into a vein in your arm or hand each time you have treatment. You have radium 223 as an injection into a vein. Your doctor will let you know about this. You might have to stop taking calcium supplements before treatment. You might also have a bone scan a week or so before. You have a blood test before treatment to make sure you're well enough to have it. So this treatment causes few side effects. This means that the cancer cells receive a high dose of radiation which can destroy them. And healthy cells receive only a low dose or no radiation. The cancer cells in the bone take up radium 223 and it then releases radiation which travels a very short distance. This is because it is similar to calcium, which is also absorbed by bone cells. are not having treatment with abiraterone.have cancer that has spread to bones but not other organs.have either had or aren't suitable for docetaxel (chemotherapy drug).had hormone treatment that is no longer working.Radium 223 is for people with prostate cancer who: You might need to travel to a different hospital for the treatment because it isn’t available in every hospital. This reduces symptoms, such as pain, and helps you feel more comfortable. Radium 223 can shrink areas of cancer cells that have spread to the bone. You have this treatment in the nuclear medicine department. It's brand name is Xofigo (pronounced zoh-fee-go). Radium 223 is a mildly radioactive form of the metal radium. This is metastatic or advanced prostate cancer. You might have it for cancer that began in the prostate and has spread to the bones. Internal radiotherapy means giving radiotherapy to the cancer from inside the body. Radium 223 is a type of internal radiotherapy treatment. Radium 223 (Xofigo) for metastatic prostate cancer
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